The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage.

The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage.

BACKGROUND:Ectopic Wnt signaling induces increased stem/progenitor cell activity in the mouse mammary gland, followed by tumor development. The Wnt signaling receptors, Lrp5/6, are uniquely required for canonical Wnt activity. Previous data has shown that the absence of Lrp5 confers resistance to Wn...

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Bibliographic Details
Main Authors: Nisha M Badders, Shruti Goel, Rod J Clark, Kristine S Klos, Soyoung Kim, Anna Bafico, Charlotta Lindvall, Bart O Williams, Caroline M Alexander
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2720450?pdf=render

Internet

http://europepmc.org/articles/PMC2720450?pdf=render

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