XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation

XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation

Somatic mutations of the estrogen receptor 1 gene (ESR1) is an emerging mechanism of acquired resistance to endocrine therapy in hormonal breast cancers. Hotspot point mutations in the ligand- binding domain of estrogen receptor α (ER) and genomic rearrangements producing ESR1 fusion genes are the t...

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Bibliographic Details
Main Authors: David Barua, Benazir Abbasi, Ananya Gupta, Sanjeev Gupta
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Heliyon
Subjects:
Cell biology
Transcriptomics
Biochemistry
Molecular biology
Cancer research
ESR1 mutations
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020320600

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http://www.sciencedirect.com/science/article/pii/S2405844020320600

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