Yinchenhao Decoction Ameliorates Alpha-Naphthylisothiocyanate Induced Intrahepatic Cholestasis in Rats by Regulating Phase II Metabolic Enzymes and Transporters

Yinchenhao Decoction Ameliorates Alpha-Naphthylisothiocyanate Induced Intrahepatic Cholestasis in Rats by Regulating Phase II Metabolic Enzymes and Transporters

Yinchenhao Decoction (YCHD), a famous traditional Chinese formula, has been used for treating cholestasis for 1000s of years. The cholagogic effect of YCHD has been widely reported, but its pharmacodynamic material and underlying therapeutic mechanism remain unclear. By using ultra-high-performance...

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Bibliographic Details
Main Authors: Ya-Xiong Yi, Yue Ding, Yong Zhang, Ning-Hui Ma, Feng Shi, Ping Kang, Zhen-Zhen Cai, Tong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
Yinchenhao Decoction
phase II metabolism
pharmacokinetics
cholestasis
bilirubin metabolism enzyme
metabolic transporter
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00510/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00510/full

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