Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human
Asthenozoospermia is a major cause of male infertility, and multiple morphological abnormalities of the flagella (MMAF) is a particularly severe form. Here, using whole-exome sequencing of 78 MMAF patients, the authors identify mutations in two WDR proteins, CFAP43 and CFAP44, and confirm that these...
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Bibliographic Details
| Main Authors: |
Charles Coutton,
Alexandra S. Vargas,
Amir Amiri-Yekta,
Zine-Eddine Kherraf,
Selima Fourati Ben Mustapha,
Pauline Le Tanno,
Clémentine Wambergue-Legrand,
Thomas Karaouzène,
Guillaume Martinez,
Serge Crouzy,
Abbas Daneshipour,
Seyedeh Hanieh Hosseini,
Valérie Mitchell,
Lazhar Halouani,
Ouafi Marrakchi,
Mounir Makni,
Habib Latrous,
Mahmoud Kharouf,
Jean-François Deleuze,
Anne Boland,
Sylviane Hennebicq,
Véronique Satre,
Pierre-Simon Jouk,
Nicolas Thierry-Mieg,
Beatrice Conne,
Denis Dacheux,
Nicolas Landrein,
Alain Schmitt,
Laurence Stouvenel,
Patrick Lorès,
Elma El Khouri,
Serge P. Bottari,
Julien Fauré,
Jean-Philippe Wolf,
Karin Pernet-Gallay,
Jessica Escoffier,
Hamid Gourabi,
Derrick R. Robinson,
Serge Nef,
Emmanuel Dulioust,
Raoudha Zouari,
Mélanie Bonhivers,
Aminata Touré,
Christophe Arnoult,
Pierre F. Ray |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-02792-7
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