A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo

A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo

The combination cancer therapy is a new strategy to circumvent drug resistance for the treatment of high metastasis and advanced malignancies. Herein, we developed a synthesized compound MPT0B451 that display inhibitory effect against histone deacetylase (HDAC) 6 and tubulin assembly. Our data demon...

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Bibliographic Details
Main Authors: Yi-Wen Wu, Kai-Cheng Hsu, Hsueh-Yun Lee, Tsui-Chin Huang, Tony E. Lin, Yi-Ling Chen, Ting-Yi Sung, Jing-Ping Liou, Wendy W. Hwang-Verslues, Shiow-Lin Pan, Wei-Chun HuangFu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Pharmacology
Subjects:
microtubule
HDAC6
G2/M arrest
apoptosis
prostate cancer
acute myeloid leukemia
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00205/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00205/full

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