About Model Validation in Bioprocessing

About Model Validation in Bioprocessing

In bioprocess engineering the Qualtiy by Design (QbD) initiative encourages the use of models to define design spaces. However, clear guidelines on how models for QbD are validated are still missing. In this review we provide a comprehensive overview of the validation methods, mathematical approache...

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Bibliographic Details
Main Authors: Vignesh Rajamanickam, Heiko Babel, Liliana Montano-Herrera, Alireza Ehsani, Fabian Stiefel, Stefan Haider, Beate Presser, Bettina Knapp
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Processes
Subjects:
bioprocess models
model validation
model calibration
quality by design
mechanistical and statistical models
hybrid models
Online Access:https://www.mdpi.com/2227-9717/9/6/961

Internet

https://www.mdpi.com/2227-9717/9/6/961

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