Class-modeling analysis reveals T-cell homeostasis disturbances involved in loss of immune control in elite controllers

Class-modeling analysis reveals T-cell homeostasis disturbances involved in loss of immune control in elite controllers

Abstract Background Despite long-lasting HIV replication control, a significant proportion of elite controller (EC) patients may experience CD4 T-cell loss. Discovering perturbations in immunological parameters could help our understanding of the mechanisms that may be operating in those patients ex...

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Main Authors: José M. Benito, María C. Ortiz, Agathe León, Luis A. Sarabia, José M. Ligos, María Montoya, Marcial Garcia, Ezequiel Ruiz-Mateos, Rosario Palacios, Alfonso Cabello, Clara Restrepo, Carmen Rodriguez, Jorge del Romero, Manuel Leal, María A. Muñoz-Fernández, José Alcamí, Felipe García, Miguel Górgolas, Norma Rallón, On behalf of ECRIS integrated in the Spanish AIDS Research Network
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Medicine
Subjects:
Elite controllers
CD4 T-cell loss
Class modeling
T-cell homeostatic parameters
CD8 exhaustion
Online Access:http://link.springer.com/article/10.1186/s12916-018-1026-6

Internet

http://link.springer.com/article/10.1186/s12916-018-1026-6

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