Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity

Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity

Broadly neutralizing antibodies targeting HIV Env could potentially be utilized as therapeutics. Here, Steinhardt et al. engineer a trispecific antibody with specificity for the receptor-binding site, a conserved Env glycan patch and the Env membrane proximal region with nearly pan-isolate neutraliz...

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Bibliographic Details
Main Authors: James J. Steinhardt, Javier Guenaga, Hannah L. Turner, Krisha McKee, Mark K. Louder, Sijy O’Dell, Chi-I Chiang, Lin Lei, Andrey Galkin, Alexander K. Andrianov, Nicole A. Doria-Rose, Robert T. Bailer, Andrew B. Ward, John R. Mascola, Yuxing Li
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03335-4

Internet

https://doi.org/10.1038/s41467-018-03335-4

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