Endogenous asymmetric dimethylarginine accumulation contributes to the suppression of myocardial mitochondrial biogenesis in type 2 diabetic rats

Endogenous asymmetric dimethylarginine accumulation contributes to the suppression of myocardial mitochondrial biogenesis in type 2 diabetic rats

Abstract Background Suppressed mitochondrial biosynthesis has been reported to be the early signal of mitochondrial dysfunction which contributes to diabetic cardiomyopathy, but the mechanism of mitochondrial biosynthesis suppression is unclear. Nitric oxide synthase inhibitor asymmetric dimethylarg...

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Bibliographic Details
Main Authors: Yan Xiong, Chun-Xia Hai, Wei-Jin Fang, Yan-Ping Lei, Xiao-Mei Li, Xin-Ke Zhou
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Nutrition & Metabolism
Subjects:
Asymmetric dimethylarginine
Diabetic cardiomyopathy
Mitochondrial biogenesis
Peroxisome proliferator-activated receptor-γ coactivator-1α
Online Access:http://link.springer.com/article/10.1186/s12986-020-00486-4

Internet

http://link.springer.com/article/10.1186/s12986-020-00486-4

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