Inonotus obliquus Polysaccharide Ameliorates Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in Mice via Activation of the NLRP3 Inflammasome

Inonotus obliquus Polysaccharide Ameliorates Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in Mice via Activation of the NLRP3 Inflammasome

Inonotus obliquus polysaccharide (IOP), the primary constituent of the parasitic fungus Inonotus obliquus, has anti-tumor, anti-inflammatory, anti-oxidation effects. However, the roles of IOP on colitis-associated cancer (CAC) are still unclear. Herein, we tested the efficacy of IOP using a mouse mo...

Full description

Bibliographic Details
Main Authors: Jiawei Li, Chao Qu, Fangfang Li, Yifang Chen, Jinjuan Zheng, Yao Xiao, Quanxin Jin, Guihua Jin, Xuezhu Huang, Dan Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
inonotus obliquus polysaccharide
CAC
AOM/DSS
NLRP3 inflammasome
proinflammatory mediators
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.621835/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.621835/full

Similar Items