Respiratory Immunization With a Whole Cell Inactivated Vaccine Induces Functional Mucosal Immunoglobulins Against Tuberculosis in Mice and Non-human Primates

Respiratory Immunization With a Whole Cell Inactivated Vaccine Induces Functional Mucosal Immunoglobulins Against Tuberculosis in Mice and Non-human Primates

Vaccination through the natural route of infection represents an attractive immunization strategy in vaccinology. In the case of tuberculosis, vaccine delivery by the respiratory route has regained interest in recent years, showing efficacy in different animal models. In this context, respiratory va...

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Bibliographic Details
Main Authors: Nacho Aguilo, Santiago Uranga, Elena Mata, Raquel Tarancon, Ana Belén Gómez, Dessislava Marinova, Isabel Otal, Marta Monzón, Juan Badiola, Dolores Montenegro, Eugenia Puentes, Esteban Rodríguez, Richard A. W. Vervenne, Claudia C. Sombroek, Frank A. W. Verreck, Carlos Martín
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Microbiology
Subjects:
whole-cell vaccine
pulmonary vaccination
animal models
mucosal immunoglobulins
opsonization
tuberculosis
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01339/full

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https://www.frontiersin.org/article/10.3389/fmicb.2020.01339/full

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