Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy

Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy

Depression is frequently reported in epilepsy patients; however, mechanisms of co-morbidity between epilepsy and depression are poorly understood. An important mechanism of depression is disinhibition within the hypothalamo–pituitary–adrenocortical (HPA) axis. We examined the functional state of the...

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Main Authors: Andrey M. Mazarati, Don Shin, Young Se Kwon, Anatol Bragin, Eduardo Pineda, Delia Tio, Anna N. Taylor, Raman Sankar
Format: Article
Language:English
Published: Elsevier 2009-06-01
Series:Neurobiology of Disease
Subjects:
Epilepsy
Depression
Co-morbidity
Hypothalamo–pituitary–adrenocortical axis
Chronic stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109000540
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spelling doaj-03f8476f5bd343b6b1d3e8f8194efbad2021-03-20T04:57:20ZengElsevierNeurobiology of Disease1095-953X2009-06-01343457461Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsyAndrey M. Mazarati0Don Shin1Young Se Kwon2Anatol Bragin3Eduardo Pineda4Delia Tio5Anna N. Taylor6Raman Sankar7Department of Pediatrics, Neurology Division, David Geffen School of Medicine at the University of California Los Angeles, BOX 951752, 22-474 MDCC, Los Angeles, CA 90095-1752, USA; Corresponding author. Fax: +1 310 825 5834.Department of Pediatrics, Neurology Division, David Geffen School of Medicine at the University of California Los Angeles, BOX 951752, 22-474 MDCC, Los Angeles, CA 90095-1752, USADepartment of Pediatrics, Neurology Division, David Geffen School of Medicine at the University of California Los Angeles, BOX 951752, 22-474 MDCC, Los Angeles, CA 90095-1752, USA; Department of Pediatrics, College of Medicine, Inha University, Incheon, Republic of KoreaDepartment of Neurology, David Geffen School of Medicine at the University of California Los Angeles, USADepartment of Pediatrics, Neurology Division, David Geffen School of Medicine at the University of California Los Angeles, BOX 951752, 22-474 MDCC, Los Angeles, CA 90095-1752, USADepartment of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, USADepartment of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles, USADepartment of Pediatrics, Neurology Division, David Geffen School of Medicine at the University of California Los Angeles, BOX 951752, 22-474 MDCC, Los Angeles, CA 90095-1752, USA; Department of Neurology, David Geffen School of Medicine at the University of California Los Angeles, USADepression is frequently reported in epilepsy patients; however, mechanisms of co-morbidity between epilepsy and depression are poorly understood. An important mechanism of depression is disinhibition within the hypothalamo–pituitary–adrenocortical (HPA) axis. We examined the functional state of the HPA axis in a rat model of co-morbidity between temporal lobe epilepsy and depression. Epilepsy was accompanied by the interictal elevation of plasma corticosterone, and by the positively combined dexamethasone/corticotropin releasing hormone test. The extent of the HPA hyperactivity was independent of recurrent seizures, but positively correlated with the severity of depressive behavior. We suggest that the observed hyperactivity of the HPA axis may underlie co-morbidity between epilepsy and depression.http://www.sciencedirect.com/science/article/pii/S0969996109000540EpilepsyDepressionCo-morbidityHypothalamo–pituitary–adrenocortical axisChronic stress
collection DOAJ
language English
format Article
sources DOAJ
author Andrey M. Mazarati
Don Shin
Young Se Kwon
Anatol Bragin
Eduardo Pineda
Delia Tio
Anna N. Taylor
Raman Sankar
spellingShingle Andrey M. Mazarati
Don Shin
Young Se Kwon
Anatol Bragin
Eduardo Pineda
Delia Tio
Anna N. Taylor
Raman Sankar
Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy
Neurobiology of Disease
Epilepsy
Depression
Co-morbidity
Hypothalamo–pituitary–adrenocortical axis
Chronic stress
author_facet Andrey M. Mazarati
Don Shin
Young Se Kwon
Anatol Bragin
Eduardo Pineda
Delia Tio
Anna N. Taylor
Raman Sankar
author_sort Andrey M. Mazarati
title Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy
title_short Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy
title_full Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy
title_fullStr Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy
title_full_unstemmed Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy
title_sort elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy
publisher Elsevier
series Neurobiology of Disease
issn 1095-953X
publishDate 2009-06-01
description Depression is frequently reported in epilepsy patients; however, mechanisms of co-morbidity between epilepsy and depression are poorly understood. An important mechanism of depression is disinhibition within the hypothalamo–pituitary–adrenocortical (HPA) axis. We examined the functional state of the HPA axis in a rat model of co-morbidity between temporal lobe epilepsy and depression. Epilepsy was accompanied by the interictal elevation of plasma corticosterone, and by the positively combined dexamethasone/corticotropin releasing hormone test. The extent of the HPA hyperactivity was independent of recurrent seizures, but positively correlated with the severity of depressive behavior. We suggest that the observed hyperactivity of the HPA axis may underlie co-morbidity between epilepsy and depression.
topic Epilepsy
Depression
Co-morbidity
Hypothalamo–pituitary–adrenocortical axis
Chronic stress
url http://www.sciencedirect.com/science/article/pii/S0969996109000540
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