Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions

Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions

The aim of this study was to develop a prodrug of ubiquinol-10 (UqH-10), the active form of ubiquinone-10 (Uq-10), for oral delivery. Bioavailability of UqH-10 is hampered by its high susceptibility to oxidation and water-insolubility. We prepared three novel <i>N,N</i>-dimethylglycine e...

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Bibliographic Details
Main Authors: Shuichi Setoguchi, Ryoji Hidaka, Nami Nagata-Akaho, Daisuke Watase, Mitsuhisa Koga, Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
bioavailability
coenzyme q<sub>10</sub>
drug delivery system
prodrug
ubiquinol
ubiquinone
Online Access:https://www.mdpi.com/1420-3049/25/3/546

Internet

https://www.mdpi.com/1420-3049/25/3/546

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