Efficient retina formation requires suppression of both Activin and BMP signaling pathways in pluripotent cells

Efficient retina formation requires suppression of both Activin and BMP signaling pathways in pluripotent cells

Retina formation requires the correct spatiotemporal patterning of key regulatory factors. While it is known that repression of several signaling pathways lead to specification of retinal fates, addition of only Noggin, a known BMP antagonist, can convert pluripotent Xenopus laevis animal cap cells...

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Bibliographic Details
Main Authors: Kimberly A. Wong, Michael Trembley, Syafiq Abd Wahab, Andrea S. Viczian
Format: Article
Language:English
Published: The Company of Biologists 2015-03-01
Series:Biology Open
Subjects:
Noggin
Retina
Xenopus
Animal cap
BMP
Activin
R-SMAD
SMAD1
SMAD2
SB431542
Dorsomorphin
Online Access:http://bio.biologists.org/content/4/4/573

Internet

http://bio.biologists.org/content/4/4/573

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