CUL5–ASB6 Complex Promotes p62/SQSTM1 Ubiquitination and Degradation to Regulate Cell Proliferation and Autophagy

CUL5–ASB6 Complex Promotes p62/SQSTM1 Ubiquitination and Degradation to Regulate Cell Proliferation and Autophagy

p62/SQSTM1 (sequestosome-1) is a key protein involved in multiple cellular bioprocesses including autophagy, nutrient sensing, cell growth, cell death, and survival. Therefore, it is implicated in human diseases such as obesity and cancer. Here, we show that the CUL5–ASB6 complex is a ubiquitin E3 l...

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Bibliographic Details
Main Authors: Liyan Gong, Kaihua Wang, Mengcheng Wang, Ronggui Hu, Huaguang Li, Daming Gao, Moubin Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
p62
ubiquitination
CUL5
ASB6
proliferation
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.684885/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.684885/full

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