Evidence for linkage of pfmdr1, pfcrt, and pfk13 polymorphisms to lumefantrine and mefloquine susceptibilities in a Plasmodium falciparum cross

Evidence for linkage of pfmdr1, pfcrt, and pfk13 polymorphisms to lumefantrine and mefloquine susceptibilities in a Plasmodium falciparum cross

Background: Lumefantrine and mefloquine are used worldwide in artemisinin-based combination therapy (ACT) of malaria. Better understanding of drug susceptibility and resistance is needed and can be obtained from studies of genetic crosses. Methods: Drug response phenotypes of a cross between Plasmod...

Full description

Bibliographic Details
Main Authors: Sean T. Windle, Kristin D. Lane, Nahla B. Gadalla, Anna Liu, Jianbing Mu, Ramoncito L. Caleon, Rifat S. Rahman, Juliana M. Sá, Thomas E. Wellems
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Malaria
Artemisinin-based combination chemotherapy
Drug resistance
Halofantrine
Quantitative trait loci analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320720300403

Internet

http://www.sciencedirect.com/science/article/pii/S2211320720300403

Similar Items