BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer’s disease

Abstract Alzheimer’s disease (AD) is a chronic progressive degenerative disease of the nervous system. Its pathogenesis is complex and is related to the abnormal expression of the amyloid β (Aβ), APP, and Tau proteins. Evidence has demonstrated that bone morphogenetic protein 4 (BMP4) is highly expr...

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Bibliographic Details
Main Authors: Xiaoqing Zhang, Juan Li, Li Ma, Hui Xu, Yun Cao, Wei Liang, Jia Ma, Z. Peter Wang, Yuyun Li
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00435-x