A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target

A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target

Abstract Background Merkel cell carcinomas (MCCs) are rare, aggressive, therapeutically-challenging skin tumours that are increasing in incidence and have poor survival rates. The majority are caused by genomic Merkel cell polyomavirus (MCPyV) integration and MCPyV T-antigen expression. Recently, a...

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Bibliographic Details
Main Authors: Lucia Cappabianca, Stefano Guadagni, Rita Maccarone, Michela Sebastiano, Alessandro Chiominto, Antonietta Rosella Farina, Andrew Reay Mackay
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Merkel cell carcinoma
Merkel cell polyomavirus
MCPyV large T-antigen
Alternative TrkAIII splicing
Oncogenic activation mechanism
Therapeutic target
Online Access:http://link.springer.com/article/10.1186/s13046-019-1425-3

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http://link.springer.com/article/10.1186/s13046-019-1425-3

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