Spatiotemporal Control of GPR37 Signaling and Its Behavioral Effects by Optogenetics

Spatiotemporal Control of GPR37 Signaling and Its Behavioral Effects by Optogenetics

Despite the progress in deorphanization of G Protein-Coupled Receptors (GPCRs), ≈100 GPCRs are still classified as orphan receptors without identified endogenous ligands and with unknown physiological functions. The lack of endogenous ligands triggering GPCR signaling has hampered the study of orpha...

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Bibliographic Details
Main Authors: Wu Zheng, Jianhong Zhou, Yanan Luan, Jianglan Yang, Yuanyuan Ge, Muran Wang, Beibei Wu, Zhongnan Wu, Xingjun Chen, Fei Li, Zhihui Li, Sergii Vakal, Wei Guo, Jiang-Fan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
GPCRs
orphan GPCRs
opto-GPR37
channelrhodopsin
optogenetics
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00095/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00095/full

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