STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic CancerSummary

STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic CancerSummary

Background & Aims: Pancreatic ductal adenocarcinoma (PDA) is a lethal chemoresistant cancer that exhibits early metastatic spread. The highly immunosuppressive PDA tumor microenvironment renders patients resistant to emerging immune-targeted therapies. Building from our prior work, we evalua...

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Bibliographic Details
Main Authors: Emily P. Vonderhaar, Nicholas S. Barnekow, Donna McAllister, Laura McOlash, Mahmoud Abu Eid, Matthew J. Riese, Vera L. Tarakanova, Bryon D. Johnson, Michael B. Dwinell
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Antitumor Immunity
Tumor Microenvironment
Flow Immunophenotyping
Tumor-Intrinsic IFNAR Signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X21000242

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X21000242

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