MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C
Chronic Hepatitis C infection is associated with a broad spectrum of liver pathologies, ranging from inflammation to fibrosis and liver cancer. Here Thabet et al. identified a polymorphism in the gene MBOAT7 that is associated with increased hepatic inflammation and higher risk of fibrosis developme...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12757 |
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doaj-040377325d9345739aef54ce9c9e39f42021-05-11T10:59:49ZengNature Publishing GroupNature Communications2041-17232016-09-01711810.1038/ncomms12757MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis CKhaled Thabet0Anastasia Asimakopoulos1Maryam Shojaei2Manuel Romero-Gomez3Alessandra Mangia4William L. Irving5Thomas Berg6Gregory J. Dore7Henning Grønbæk8David Sheridan9Maria Lorena Abate10Elisabetta Bugianesi11Martin Weltman12Lindsay Mollison13Wendy Cheng14Stephen Riordan15Janett Fischer16Ulrich Spengler17Jacob Nattermann18Ahmed Wahid19Angela Rojas20Rose White21Mark W. Douglas22Duncan McLeod23Elizabeth Powell24Christopher Liddle25David van der Poorten26Jacob George27Mohammed Eslam28International Liver Disease Genetics ConsortiumStorr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of SydneyStorr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of SydneyCentre for Immunology and Allergy Research, Westmead Institute for Medical ResearchUnit for The Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de ValmeDivision of Hepatology, Ospedale Casa Sollievo della Sofferenza, IRCCSNIHR Biomedical Research Unit in Gastroenterology and the Liver, University of NottinghamSection of Hepatology, Clinic for Gastroenterology and Rheumatology, University Clinic LeipzigKirby Institute, The University of New South WalesDepartment of Hepatology and Gastroenterology, Aarhus University HospitalInstitute of Translational and Stratified Medicine, Plymouth UniversityDivision of Gastroenterology and Hepatology, Department of Medical Science, University of TurinDivision of Gastroenterology and Hepatology, Department of Medical Science, University of TurinDepartment of Gastroenterology and Hepatology, Nepean HospitalDepartment of Gastroenterology and Hepatology, Fremantle HospitalDepartment of Gastroenterology and Hepatology, Royal Perth HospitalGastrointestinal and Liver Unit, Prince of Wales Hospital and University of New South WalesSection of Hepatology, Clinic for Gastroenterology and Rheumatology, University Clinic LeipzigDepartment of Internal Medicine I, University of BonnDepartment of Internal Medicine I, University of BonnDepartment of Biochemistry, Faculty of Pharmacy, Minia UniversityUnit for The Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de ValmeStorr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of SydneyStorr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of SydneyDepartment of Anatomical Pathology, Institute of Clinical Pathology and Medical Research (ICPMR), Westmead HospitalPrincess Alexandra Hospital, School of Medicine, The University of QueenslandStorr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of SydneyStorr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of SydneyStorr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of SydneyStorr Liver Centre, Westmead Institute for Medical Research and Westmead Hospital, University of SydneyChronic Hepatitis C infection is associated with a broad spectrum of liver pathologies, ranging from inflammation to fibrosis and liver cancer. Here Thabet et al. identified a polymorphism in the gene MBOAT7 that is associated with increased hepatic inflammation and higher risk of fibrosis development and progression.https://doi.org/10.1038/ncomms12757 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Khaled Thabet Anastasia Asimakopoulos Maryam Shojaei Manuel Romero-Gomez Alessandra Mangia William L. Irving Thomas Berg Gregory J. Dore Henning Grønbæk David Sheridan Maria Lorena Abate Elisabetta Bugianesi Martin Weltman Lindsay Mollison Wendy Cheng Stephen Riordan Janett Fischer Ulrich Spengler Jacob Nattermann Ahmed Wahid Angela Rojas Rose White Mark W. Douglas Duncan McLeod Elizabeth Powell Christopher Liddle David van der Poorten Jacob George Mohammed Eslam International Liver Disease Genetics Consortium |
| spellingShingle |
Khaled Thabet Anastasia Asimakopoulos Maryam Shojaei Manuel Romero-Gomez Alessandra Mangia William L. Irving Thomas Berg Gregory J. Dore Henning Grønbæk David Sheridan Maria Lorena Abate Elisabetta Bugianesi Martin Weltman Lindsay Mollison Wendy Cheng Stephen Riordan Janett Fischer Ulrich Spengler Jacob Nattermann Ahmed Wahid Angela Rojas Rose White Mark W. Douglas Duncan McLeod Elizabeth Powell Christopher Liddle David van der Poorten Jacob George Mohammed Eslam International Liver Disease Genetics Consortium MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C Nature Communications |
| author_facet |
Khaled Thabet Anastasia Asimakopoulos Maryam Shojaei Manuel Romero-Gomez Alessandra Mangia William L. Irving Thomas Berg Gregory J. Dore Henning Grønbæk David Sheridan Maria Lorena Abate Elisabetta Bugianesi Martin Weltman Lindsay Mollison Wendy Cheng Stephen Riordan Janett Fischer Ulrich Spengler Jacob Nattermann Ahmed Wahid Angela Rojas Rose White Mark W. Douglas Duncan McLeod Elizabeth Powell Christopher Liddle David van der Poorten Jacob George Mohammed Eslam International Liver Disease Genetics Consortium |
| author_sort |
Khaled Thabet |
| title |
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
| title_short |
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
| title_full |
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
| title_fullStr |
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
| title_full_unstemmed |
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C |
| title_sort |
mboat7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis c |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-09-01 |
| description |
Chronic Hepatitis C infection is associated with a broad spectrum of liver pathologies, ranging from inflammation to fibrosis and liver cancer. Here Thabet et al. identified a polymorphism in the gene MBOAT7 that is associated with increased hepatic inflammation and higher risk of fibrosis development and progression. |
| url |
https://doi.org/10.1038/ncomms12757 |
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