Orai1 Channels Are Essential for Amplification of Glutamate-Evoked Ca2+ Signals in Dendritic Spines to Regulate Working and Associative Memory

Orai1 Channels Are Essential for Amplification of Glutamate-Evoked Ca2+ Signals in Dendritic Spines to Regulate Working and Associative Memory

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Summary: Store-operated Orai1 calcium channels function as highly Ca2+-selective ion channels and are broadly expressed in many tissues including the central nervous system, but their contributions to cognitive processing are largely unknown. Here, we report that many measures of synaptic, cellular,...

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Bibliographic Details
Main Authors: Mohammad Mehdi Maneshi, Anna B. Toth, Toshiyuki Ishii, Kotaro Hori, Shogo Tsujikawa, Andrew K. Shum, Nisha Shrestha, Megumi Yamashita, Richard J. Miller, Jelena Radulovic, Geoffrey T. Swanson, Murali Prakriya
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
Orai1
calcium
STIM1
CRAC channels
dendritic spines
dendritic calcium signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720314534

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http://www.sciencedirect.com/science/article/pii/S2211124720314534

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