Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

Mobilization of retrotransposons to new genomic locations is a significant driver of mammalian genome evolution, but these mutagenic events can also cause genetic disorders. In humans, retrotransposon mobilization is mediated primarily by proteins encoded by LINE-1 (L1) retrotransposons, which mobil...

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Bibliographic Details
Main Authors: Marie MacLennan, Marta García-Cañadas, Judith Reichmann, Elena Khazina, Gabriele Wagner, Christopher J Playfoot, Carmen Salvador-Palomeque, Abigail R Mann, Paula Peressini, Laura Sanchez, Karen Dobie, David Read, Chao-Chun Hung, Ragnhild Eskeland, Richard R Meehan, Oliver Weichenrieder, Jose Luis García-Pérez, Ian R Adams
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
L1
retrotransposon
LINE-1
pluripotent
germline
Tex19.1
Online Access:https://elifesciences.org/articles/26152

Internet

https://elifesciences.org/articles/26152

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