SPIN90 Modulates Long-Term Depression and Behavioral Flexibility in the Hippocampus

SPIN90 Modulates Long-Term Depression and Behavioral Flexibility in the Hippocampus

The importance of actin-binding proteins (ABPs) in the regulation of synapse morphology and plasticity has been well established. SH3 protein interacting with Nck, 90 kDa (SPIN90), an Nck-interacting protein highly expressed in synapses, is essential for actin remodeling and dendritic spine morpholo...

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Bibliographic Details
Main Authors: Dae Hwan Kim, Minkyung Kang, Chong-Hyun Kim, Yun Hyun Huh, In Ha Cho, Hyun-Hee Ryu, Kyung Hwun Chung, Chul-Seung Park, Sangmyung Rhee, Yong-Seok Lee, Woo Keun Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
SPIN90 (SH3 protein interacting with Nck
90 kDa)
long-term depression (LTD)
behavioral flexibility
synaptic plasticity
learning and memory
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00295/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00295/full

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