Long-Term Safety Issues of iPSC-Based Cell Therapy in a Spinal Cord Injury Model: Oncogenic Transformation with Epithelial-Mesenchymal Transition

Long-Term Safety Issues of iPSC-Based Cell Therapy in a Spinal Cord Injury Model: Oncogenic Transformation with Epithelial-Mesenchymal Transition

Previously, we described the safety and therapeutic potential of neurospheres (NSs) derived from a human induced pluripotent stem cell (iPSC) clone, 201B7, in a spinal cord injury (SCI) mouse model. However, several safety issues concerning iPSC-based cell therapy remain unresolved. Here, we investi...

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Bibliographic Details
Main Authors: Satoshi Nori, Yohei Okada, Soraya Nishimura, Takashi Sasaki, Go Itakura, Yoshiomi Kobayashi, Francois Renault-Mihara, Atsushi Shimizu, Ikuko Koya, Rei Yoshida, Jun Kudoh, Masato Koike, Yasuo Uchiyama, Eiji Ikeda, Yoshiaki Toyama, Masaya Nakamura, Hideyuki Okano
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115000272

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http://www.sciencedirect.com/science/article/pii/S2213671115000272

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