A novel bioengineered fragment peptide of Vasostatin-1 exerts smooth muscle pharmacological activities and anti-angiogenic effects via blocking VEGFR signalling pathway

A novel bioengineered fragment peptide of Vasostatin-1 exerts smooth muscle pharmacological activities and anti-angiogenic effects via blocking VEGFR signalling pathway

Chromogranin A (CgA) is a hydrophilic glycoprotein released by post-ganglionic sympathetic neurons. CgA consists of a single peptide chain containing numerous paired basic residues, which are typical cleavage sites in prohormones to generate bioactive peptides. It is recognized as a diagnostic and p...

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Bibliographic Details
Main Authors: Ran Wei, Qiushuang Wu, Nana Ai, Lei Wang, Mei Zhou, Chris Shaw, Tianbao Chen, Richard Dequan Ye, Wei Ge, Shirley W.I. Siu, Hang Fai Kwok
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Chromogranin A
Vasostatin-1
Anti-angiogenesis
VEGFR2
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021001847

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http://www.sciencedirect.com/science/article/pii/S2001037021001847

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