Glial and Neuronal Glutamate Transporters Differ in the Na+ Requirements for Activation of the Substrate-Independent Anion Conductance

Glial and Neuronal Glutamate Transporters Differ in the Na+ Requirements for Activation of the Substrate-Independent Anion Conductance

Excitatory amino acid transporters (EAATs) are secondary active transporters of L-glutamate and L- or D-aspartate. These carriers also mediate a thermodynamically uncoupled anion conductance that is gated by Na+ and substrate binding. The activation of the anion channel by binding of Na+ alone, howe...

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Bibliographic Details
Main Authors: Christopher B. Divito, Jenna E. Borowski, Nathan G. Glasgow, Aneysis D. Gonzalez-Suarez, Delany Torres-Salazar, Jon W. Johnson, Susan G. Amara
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neurotransmitter transporters
chloride channels
electrophysiology
glutamate
excitatory amino acid transporter
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00150/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00150/full

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