DNA Vaccine Administered by Cationic Lipoplexes or by In Vivo Electroporation Induces Comparable Antibody Responses against SARS-CoV-2 in Mice

DNA Vaccine Administered by Cationic Lipoplexes or by In Vivo Electroporation Induces Comparable Antibody Responses against SARS-CoV-2 in Mice

In view of addressing the global necessity of an effective vaccine in the SARS-CoV-2 pandemic, a plasmid DNA vaccine, expressing for the spike (S) protein and formulated in lipoplexes, was manufactured and tested for in vitro transfection and in vivo immunogenicity. Blank cationic liposomes of 130.9...

Full description

Bibliographic Details
Main Authors: Allegra Peletta, Eakachai Prompetchara, Kittipan Tharakhet, Papatsara Kaewpang, Supranee Buranapraditkun, Teerasit Techawiwattanaboon, Tayeb Jbilou, Pratomporn Krangvichian, Sunee Sirivichayakul, Suwimon Manopwisedjaroen, Arunee Thitithanyanont, Kanitha Patarakul, Kiat Ruxrungtham, Chutitorn Ketloy, Gerrit Borchard
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Vaccines
Subjects:
DNA vaccines
SARS-CoV-2
cationic liposomes
lipoplexes
immunogenicity
Online Access:https://www.mdpi.com/2076-393X/9/8/874

Internet

https://www.mdpi.com/2076-393X/9/8/874

Similar Items