Emerging roles of H3K9me3, SETDB1 and SETDB2 in therapy-induced cellular reprogramming

Emerging roles of H3K9me3, SETDB1 and SETDB2 in therapy-induced cellular reprogramming

Abstract Background A multitude of recent studies has observed common epigenetic changes develop in tumour cells of multiple lineages following exposure to stresses such as hypoxia, chemotherapeutics, immunotherapy or targeted therapies. A significant increase in the transcriptionally repressive mar...

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Bibliographic Details
Main Authors: Joachim Torrano, Abdullah Al Emran, Heinz Hammerlindl, Helmut Schaider
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Clinical Epigenetics
Subjects:
SETDB1
SETDB2
H3K9me3
IFN signalling
Adaptive resistance
Transcriptional reprogramming
Online Access:http://link.springer.com/article/10.1186/s13148-019-0644-y

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http://link.springer.com/article/10.1186/s13148-019-0644-y

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