BAP1 Status Determines the Sensitivity of Malignant Mesothelioma Cells to Gemcitabine Treatment

BAP1 Status Determines the Sensitivity of Malignant Mesothelioma Cells to Gemcitabine Treatment

Malignant mesothelioma (MMe) is a cancer with poor prognosis and resistance to standard treatments. Recent reports have highlighted the role of the BRCA1 associated protein 1 gene (BAP1) in the development of MMe. In this study, the chemosensitivity of human mesothelioma cell lines carrying BAP1 wil...

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Bibliographic Details
Main Authors: Alice Guazzelli, Parisa Meysami, Emyr Bakker, Constantinos Demonacos, Antonio Giordano, Marija Krstic-Demonacos, Luciano Mutti
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
malignant mesothelioma
BAP1
gemcitabine
chemoresistance
DNA damage
cell cycle
apoptosis
Online Access:http://www.mdpi.com/1422-0067/20/2/429

Internet

http://www.mdpi.com/1422-0067/20/2/429

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