Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease.

Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease.

Dysregulated signaling cascades alter energy metabolism and promote cell proliferation and cyst expansion in polycystic kidney disease (PKD). Here we tested whether metabolic reprogramming towards aerobic glycolysis ("Warburg effect") plays a pathogenic role in male heterozygous Han:SPRD r...

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Bibliographic Details
Main Authors: Meliana Riwanto, Sarika Kapoor, Daniel Rodriguez, Ilka Edenhofer, Stephan Segerer, Rudolf P Wüthrich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4708993?pdf=render

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http://europepmc.org/articles/PMC4708993?pdf=render

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