Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques

Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques

Mutations in presenilin-1 (PS-1) account for the majority of familial Alzheimer's disease (AD). While increasing Abeta42 is one mechanism whereby PS-1 mutations are thought to exert their pathogenic effect, little is known about the role of tau in PS-1 AD. This study compares staining (AT8 and...

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Bibliographic Details
Main Authors: Claire E Shepherd, Gillian C Gregory, James C Vickers, William S Brooks, John B.J Kwok, Peter R Schofield, Jillian J Kril, Glenda M Halliday
Format: Article
Language:English
Published: Elsevier 2004-02-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Presenilin
Tau
Phosphorylation
Cotton wool plaques
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103002134

Internet

http://www.sciencedirect.com/science/article/pii/S0969996103002134

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