Electrostatic Interaction Between NS1 and Negatively Charged Lipids Contributes to Flavivirus Replication Organelles Formation

Electrostatic Interaction Between NS1 and Negatively Charged Lipids Contributes to Flavivirus Replication Organelles Formation

Flavivirus replication occurs in membranous replication compartments, also known as replication organelles (ROs) derived from the host ER membrane. Our previous study showed that the non-structural (NS) protein 1 (NS1) is the essential factor for RO creation by hydrophobic insertion into the ER memb...

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Bibliographic Details
Main Authors: Yali Ci, Yang Yang, Caimin Xu, Cheng-Feng Qin, Lei Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Microbiology
Subjects:
flavivirus
ER remodeling
replication organelles
PIP
non-structural protein 1
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.641059/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.641059/full

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