The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis

The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis

Aging is one of the major pathologic factors associated with osteoarthritis (OA). Recently, numerous reports have demonstrated the impact of sirtuin-1 (Sirt1), which is the NAD-dependent deacetylase, on human aging. It has been demonstrated that Sirt1 induces osteogenic and chondrogenic differentiat...

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Bibliographic Details
Main Authors: Koh Terauchi, Hajime Kobayashi, Kanaka Yatabe, Naoko Yui, Hiroto Fujiya, Hisateru Niki, Haruki Musha, Kazuo Yudoh
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:International Journal of Molecular Sciences
Subjects:
osteoarthritis
NAD-dependent deacetylase
sirtuin
Runx2
chondrocytes
Online Access:http://www.mdpi.com/1422-0067/17/7/1019

Internet

http://www.mdpi.com/1422-0067/17/7/1019

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