CX3CL1, a chemokine finely tuned to adhesion: critical roles of the stalk glycosylation and the membrane domain

CX3CL1, a chemokine finely tuned to adhesion: critical roles of the stalk glycosylation and the membrane domain

The multi-domain CX3CL1 transmembrane chemokine triggers leukocyte adherence without rolling and migration by presenting its chemokine domain (CD) to its receptor CX3CR1. Through the combination of functional adhesion assays with structural analysis using FRAP, we investigated the functional role of...

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Bibliographic Details
Main Authors: Mariano A. Ostuni, Julie Guellec, Patricia Hermand, Pauline Durand, Christophe Combadière, Frédéric Pincet, Philippe Deterre
Format: Article
Language:English
Published: The Company of Biologists 2014-11-01
Series:Biology Open
Subjects:
Chemokine
Adhesion
FRAP
Glycosylation
GPCR
Online Access:http://bio.biologists.org/content/3/12/1173

Internet

http://bio.biologists.org/content/3/12/1173

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