Doxycycline exposure during adolescence and future risk of non-affective psychosis and bipolar disorder: a total population cohort study

Abstract Doxycycline has been hypothesized to prevent development of severe mental illness (SMI) through the suppression of microglia, especially if administered during the intense synaptic pruning period of adolescence. However, results from register studies on potential benefits differ considerabl...

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Bibliographic Details
Main Authors: Fredrik Upmark, Hugo Sjöqvist, Joseph F. Hayes, Christina Dalman, Håkan Karlsson
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01574-6