Inhibition of CPU0213, a Dual Endothelin Receptor Antagonist, on Apoptosis via Nox4-Dependent ROS in HK-2 Cells

Inhibition of CPU0213, a Dual Endothelin Receptor Antagonist, on Apoptosis via Nox4-Dependent ROS in HK-2 Cells

Background/Aims: Our previous studies have indicated that a novel endothelin receptor antagonist CPU0213 effectively normalized renal function in diabetic nephropathy. However, the molecular mechanisms mediating the nephroprotective role of CPU0213 remain unknown. Methods and Results: In the present...

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Bibliographic Details
Main Authors: Qing Li, Ji Li, Hua Shao, Xiao-Xue Li, Feng Yu, Ming Xu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Nox4
Apoptosis
Endothelin-1
HK-2 cells
Diabetic nephropathy
Online Access:http://www.karger.com/Article/FullText/445615

Internet

http://www.karger.com/Article/FullText/445615

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