Completing the Enalaprilat Excretion Pathway—Renal Handling by the Proximal Tubule

Completing the Enalaprilat Excretion Pathway—Renal Handling by the Proximal Tubule

Background: Enalapril is often used in the treatment of cardiovascular diseases. Clinical data suggest that the urinary excretion of enalaprilat, the active metabolite of enalapril, is mediated by renal transporters. We aimed to identify enalaprilat specificity for renal proximal tubular transporter...

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Bibliographic Details
Main Authors: Nori J. L. Smeets, Carlijn H. C. Litjens, Jeroen J. M. W. van den Heuvel, Hedwig van Hove, Petra van den Broek, Frans G. M. Russel, Jan B. Koenderink, Saskia N. de Wildt
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pharmaceutics
Subjects:
enalapril
enalaprilat
drug transporters
proximal tubule cell
Online Access:https://www.mdpi.com/1999-4923/12/10/935

Internet

https://www.mdpi.com/1999-4923/12/10/935

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