Combination approaches with immune checkpoint blockade in cancer therapy

In healthy individuals, immune checkpoint molecules prevent autoimmune responses and limit immune cell-mediated tissue damage. Tumors frequently exploit these molecules to evade eradication by the immune system. Over the past years, immune checkpoint blockade of cytotoxic T lymphocyte antigen-4 (CTL...

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Bibliographic Details
Main Authors: Maarten Swart, Inge Verbrugge, Joost Beltman
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Oncology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00233/full