Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation

Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation

Post-translational modifications (PTMs) within the first 17 amino acids (Nt17) of the Huntingtin protein (Htt) have been shown to inhibit the aggregation and attenuate the toxicity of mutant Htt proteins in vitro and in various models of Huntington’s disease. Here, we expand on these studies by inve...

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Bibliographic Details
Main Authors: Anass Chiki, Zhidian Zhang, Kolla Rajasekhar, Luciano A. Abriata, Iman Rostami, Lucien F. Krapp, Driss Boudeffa, Matteo Dal Peraro, Hilal A. Lashuel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
post-translational modifications
huntingtin
molecular dynamics simulation
chemical semi-synthesis
atomic force microscope
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.686086/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.686086/full

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