Frequency of Gluten-Reactive T Cells in Active Celiac Lesions Estimated by Direct Cell Cloning

Frequency of Gluten-Reactive T Cells in Active Celiac Lesions Estimated by Direct Cell Cloning

Chronic inflammation of the small intestine in celiac disease is driven by activation of CD4+ T cells that recognize gluten peptides presented by disease-associated HLA-DQ molecules. We have performed direct cell cloning of duodenal biopsies from five untreated and one refractory celiac disease pati...

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Bibliographic Details
Main Authors: Shuo-Wang Qiao, Shiva Dahal-Koirala, Linn M. Eggesbø, Knut E. A. Lundin, Ludvig M. Sollid
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
celiac disease
gluten
T cells
epitope
HLA
direct cloning
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.646163/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.646163/full

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