MHC Class I-Restricted TCR-Transgenic CD4<sup>+ </sup>T Cells Against STEAP1 Mediate Local Tumor Control of Ewing Sarcoma In Vivo

MHC Class I-Restricted TCR-Transgenic CD4<sup>+ </sup>T Cells Against STEAP1 Mediate Local Tumor Control of Ewing Sarcoma In Vivo

In this study we report the functional comparison of T cell receptor (TCR)-engineered major histocompatibility complex (MHC) class I-restricted CD4<sup>+</sup> versus CD8<sup>+</sup> T cells targeting a peptide from<i> six transmembrane epithelial antigen of the prostat...

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Bibliographic Details
Main Authors: Sebastian J. Schober, Melanie Thiede, Hendrik Gassmann, Carolin Prexler, Busheng Xue, David Schirmer, Dirk Wohlleber, Stefanie Stein, Thomas G. P. Grünewald, Dirk H. Busch, Guenther H. S. Richter, Stefan E. G. Burdach, Uwe Thiel
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
adoptive T cell transfer
CD4<sup>+</sup> T cells
allorepertoire-derived TCR
Ewing sarcoma
Online Access:https://www.mdpi.com/2073-4409/9/7/1581

Internet

https://www.mdpi.com/2073-4409/9/7/1581

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