Feasibility of predicting allele specific expression from DNA sequencing using machine learning

Feasibility of predicting allele specific expression from DNA sequencing using machine learning

Abstract Allele specific expression (ASE) concerns divergent expression quantity of alternative alleles and is measured by RNA sequencing. Multiple studies show that ASE plays a role in hereditary diseases by modulating penetrance or phenotype severity. However, genome diagnostics is based on DNA se...

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Bibliographic Details
Main Authors: Zhenhua Zhang, Freerk van Dijk, Niek de Klein, Mariëlle E van Gijn, Lude H Franke, Richard J Sinke, Morris A Swertz, K Joeri van der Velde
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-89904-y

Internet

https://doi.org/10.1038/s41598-021-89904-y

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