Inhibition of PI3Kδ Enhances Poly I:C-Induced Antiviral Responses and Inhibits Replication of Human Metapneumovirus in Murine Lungs and Human Bronchial Epithelial Cells

Inhibition of PI3Kδ Enhances Poly I:C-Induced Antiviral Responses and Inhibits Replication of Human Metapneumovirus in Murine Lungs and Human Bronchial Epithelial Cells

Viral infections of the airway can exacerbate respiratory diseases, such as asthma or chronic obstructive pulmonary disease (COPD), and accelerate disease progression. Phosphoinositide 3-kinase (PI3K)δ, a class 1A PI3K, has been studied as a potential target for achieving anti-oncogenic and anti-inf...

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Bibliographic Details
Main Authors: Akitaka Fujita, Keiko Kan-o, Ken Tonai, Norio Yamamoto, Tomohiro Ogawa, Satoru Fukuyama, Yoichi Nakanishi, Koichiro Matsumoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
poly I:C
phosphoinositide 3-kinase δ
IC87114
programmed death 1 ligand 1
interferon
bronchial epithelial cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00432/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00432/full

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