Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat

Multiple laboratories have recently demonstrated that long-term dopaminergic transplants form Lewy bodies in patients with Parkinson's disease. Debate has arisen as to whether these Lewy bodies form from the transfer of alpha synuclein from the host to the graft or whether they form from intrin...

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Bibliographic Details
Main Authors: Jeffrey H. Kordower, Hemraj B. Dodiya, Adam M. Kordower, Brian Terpstra, Katrina Paumier, Lalitha Madhavan, Caryl Sortwell, Kathy Steece-Collier, Timothy J. Collier
Format: Article
Language:English
Published: Elsevier 2011-09-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111001550