Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.

Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.

Lymphoblastoid cell lines (LCLs), originally collected as renewable sources of DNA, are now being used as a model system to study genotype-phenotype relationships in human cells, including searches for QTLs influencing levels of individual mRNAs and responses to drugs and radiation. In the course of...

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Bibliographic Details
Main Authors: Edwin Choy, Roman Yelensky, Sasha Bonakdar, Robert M Plenge, Richa Saxena, Philip L De Jager, Stanley Y Shaw, Cara S Wolfish, Jacqueline M Slavik, Chris Cotsapas, Manuel Rivas, Emmanouil T Dermitzakis, Ellen Cahir-McFarland, Elliott Kieff, David Hafler, Mark J Daly, David Altshuler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2583954?pdf=render

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http://europepmc.org/articles/PMC2583954?pdf=render

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