Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.
Lymphoblastoid cell lines (LCLs), originally collected as renewable sources of DNA, are now being used as a model system to study genotype-phenotype relationships in human cells, including searches for QTLs influencing levels of individual mRNAs and responses to drugs and radiation. In the course of...
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-11-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC2583954?pdf=render |