Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines.
Lymphoblastoid cell lines (LCLs), originally collected as renewable sources of DNA, are now being used as a model system to study genotype-phenotype relationships in human cells, including searches for QTLs influencing levels of individual mRNAs and responses to drugs and radiation. In the course of...
Main Authors: | Edwin Choy, Roman Yelensky, Sasha Bonakdar, Robert M Plenge, Richa Saxena, Philip L De Jager, Stanley Y Shaw, Cara S Wolfish, Jacqueline M Slavik, Chris Cotsapas, Manuel Rivas, Emmanouil T Dermitzakis, Ellen Cahir-McFarland, Elliott Kieff, David Hafler, Mark J Daly, David Altshuler |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-11-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC2583954?pdf=render |
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