The next-generation sphingosine-1 receptor modulator BAF312 (siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis

The next-generation sphingosine-1 receptor modulator BAF312 (siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis

Autoimmune diseases of the central nervous system (CNS) like multiple sclerosis (MS) are characterized by inflammation and demyelinated lesions in white and grey matter regions. While inflammation is present at all stages of MS, it is more pronounced in the relapsing forms of the disease, whereas pr...

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Bibliographic Details
Main Authors: Petra Hundehege, Manuela Cerina, Susann Eichler, Christian Thomas, Alexander M Herrmann, Kerstin Göbel, Thomas Müntefering, Juncal Fernandez-Orth, Stefanie Bock, Venu Narayanan, Thomas Budde, Erwin-Josef Speckmann, Heinz Wiendl, Anna Schubart, Tobias Ruck, Sven G Meuth
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
multiple sclerosis; focal experimental autoimmune encephalomyelitis; cortical grey matter; white matter; BAF312; neuroaxonal damage; neuroprotection
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=11;spage=1950;epage=1960;aulast=Hundehege

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=11;spage=1950;epage=1960;aulast=Hundehege

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