The PERK Branch of the Unfolded Protein Response Promotes DLL4 Expression by Activating an Alternative Translation Mechanism

The PERK Branch of the Unfolded Protein Response Promotes DLL4 Expression by Activating an Alternative Translation Mechanism

Delta-like 4 (DLL4) is a pivotal endothelium specific Notch ligand that has been shown to function as a regulating factor during physiological and pathological angiogenesis. DLL4 functions as a negative regulator of angiogenic branching and sprouting. Interestingly, <i>Dll4</i> is with &...

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Bibliographic Details
Main Authors: Manon Jaud, Céline Philippe, Loic Van Den Berghe, Christèle Ségura, Laurent Mazzolini, Stéphane Pyronnet, Henrik Laurell, Christian Touriol
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
DLL4 (delta like ligand 4)
angiogenesis
IRES (internal ribosome entry site)
hypoxia
endoplasmic reticulum stress
UPR (unfolded protein response)
PERK (PKR-Like endoplasmic reticulum kinase)
Online Access:https://www.mdpi.com/2072-6694/11/2/142

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https://www.mdpi.com/2072-6694/11/2/142

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